Vědecké publikace

Oddělení laboratoří toxikogenomiky

Publikace OLT

vydané v roce 2010:
Chou YC, Chung YT, Liu TY, Wang SY, Chau GY, Chi CW, Soucek P, Krausz KW, Gelboin HV, Lee CH, Ueng YF. (2010) The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes. J Pharm Sci 99(2):1063-77.

Mohelnikova-Duchonova B, Vrana D, Holcatova I, Ryska M, Smerhovsky Z, Soucek P. (2009) CYP2A13, ADH1B nd ADH1C Gene Polymorphisms and Pancreatic Cancer Risk. Pancreas 39(2):144-148.

Linhart I, Mráz J, Scharff J, Krouzelka J, Dusková S, Nohová H, Vodicková L. (2010) New urinary metabolites formed from ring-oxidized metabolic intermediates of styrene. Chem Res Toxicol 23(1):251-7.

Vrana D, Novotny J, Holcatova I, Hlavata I, Soucek P. (2010) CYP1B1 gene polymorphism modifies pancreatic cancer risk but not survival. Neoplasma 57(1):15-9.

vydané v roce 2009:
Holcátová I, Souček P, Vrána D, Slámová A, Schejbalová M, Ryska M, Brabec M. (2009) Nádory slinivky břišní II. Potenciální rizikové faktory. Praktický lékař 8:462.

Hubackova M, Vaclavikova R, Mrhalova M, Kubackova K, Kodet R, Gut I and Soucek P. (2009) NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not co-segregate with clinico-pathological characteristcs of human mammary tumors. Pharmacogenet Genomics 19(7):505-512.

Kleibl Z, Havranek O, Hlavata I, Novotny J, Sevcik J, Pohlreich P, Soucek P. (2009) The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. Eur J Cancer, 45(4):618-24.

Kovár J, Ehrlichová M, Smejkalová B, Zanardi I, Ojima I, Gut I. (2009) Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells. Anticancer Res 29(8):2951-60.

Manini P, De Palma G, Andreoli R, Marczynski B, Hanova M, Mozzoni P, Naccarati A, Vodickova L, Hlavac P, Mutti A, Vodicka P. (2009) Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers. Toxicol Lett 190(1):41-7.

Mikes P, Korínek M, Linhart I, Krouzelka J, Frantík E, Vodicková L, Neufussová L. (2009) Excretion of urinary N7 guanine and N3 adenine DNA adducts in mice after inhalation of styrene. Toxicol Lett 184(1):33-7.

Pardini B, Naccarati A, Polakova V, Smerhovsky Z, Hlavata I, Soucek P, Novotny J, Vodickova L, Tomanova V, Landi S, Vodicka P (2009) NBN 657del(5) heterozygous mutations and colorectal cancer risk in the Czech Republic. Mutat Res- Fund Mol M 666(1-2):64-7.

Pechlivanis S, Bermejo JL, Pardini B, Naccarati A, Vodickova L, Novotny J, Hemminki K, Vodicka P, Försti A. (2009) Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol 160(6):933-40.

Polakova V, Pardini B, Naccarati A, Landi S, Slyskova J, Novotny J, Vodickova L, Bermejo JL, Hanova M, Smerhovsky Z, Tulupova E, Kumar R, Hemminki K, Vodicka P. (2009) Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic. Hum Mutat 30(4):661-8.

Ueng YF, Chen CC, Tsai CC, Soucek P. (2009) Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. J Ethnopharmacol 10;126(3):437-46.

Vodicka P, Naccarati A, Vodickova L, Polakova V, Dusinska M, Musak L, Halasova E, Susova S, Soucek P, Hemminki K. (2009) Do GST polymorphisms modulate the frequency of chromosomal aberrations in healthy subjects? Environ Health Perspect 117(9):A384-5.

Vrana D, Pikhart H, Mohelnikova-Duchonova H, Holcatova I, Strnad R, Slamova A, Schejbalova M, Ryska M, Susova S, Soucek P. (2009) The association between Glutathione S-transferase Gene polymorphisms and pancreatic cancer in Central European Slavonic population. Mutat Res-Gen Tox Environm Mutag 2009 Sep 26. [Epub ahead of print].

vydané v roce 2008:
Kleibl Z, Havranek O, Novotny J, Kleiblova P, Soucek P, Pohlreich P. (2008) Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations Breast Cancer Res Treat;112(1):159-64.

Musak L, Soucek P, Vodickova L, Naccarati A, Halasova E, Polakova V, Slyskova J, Susova S, Buchancova J, Smerhovsky Z, Sedikova J, Klimentova G, Osina O, Hemminki K, Vodicka P. (2008) Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes. Mutat Res- Fund Mol M, 10;641(1-2):36-42.

Soucek P, Xenobiotics, In: Encyclopedia of Cancer, Schwab, M (Ed.), 2nd ed., 2008, Springer Verlag, 3235 pages.

Vaclavikova, Kondrova E, Ehrlichova M, Boumendjel A, Kovar J, Stopka P, Soucek P and Gut I (2008) The effect of flavonoid derivatives on doxorubicin transport and metabolism. Bioorg Med Chem. 16(4):2034-42.

Vaclavikova R, Nordgard SH, Alnaes GIG, Hubackova M, Kubala E, Kodet R, Mrhalova M, Novotny J, Gut I, Kristensen VN and Soucek P (2008) Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients, Pharmacogenet Genomics 18(3):263-273.

vydané v roce 2007:
Hubáčková M, Václavíková R, Kubala E, Kodet R, Mrhalová M, Novotný J, Vrána D, Gut I a Souček P. (2007) Úloha exprese genů chinonoxidoreduktázy 1 a 2 v rozvoji karcinomu prsu. Klinická Onkologie, 5:337-341.

Kondrová E, Stopka P, Souček P (2007) Cytochrome P450 destruction by metabolites of benzene and the formation of hydroxyl radicals in minipig liver microsomes. Toxicol in vitro, 21(4):566-575.

Kubala E, Kubáčková K, Horský S, Václavíková R, Souček P, Mrhalová M, Kodet R, Roth Z, Tomášek L a Gut I (2007) Individuální rozdíly farmakokinetiky Taxolu u pacientek s rakovinou prsu. Klin. Farmakol. Farm., 21:7-11.

Paracchini V, Raimondi S, Gram IT, Kang D, Kocabas NA, Kristensen VN, Li D, Parl FF, Rylander-Rudqvist T, Soucek P, Zheng W, Wedren S, Taioli E. (2007) Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review. Am J Epidemiol. 165(2):115-25.

Slyskova J, Dusinska M, Kuricova M, Soucek P, Vodickova L, Susova S, Naccarati A, Tulupova E, Vodicka P. (2007) Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotoxicity and individual susceptibility in styrene-exposed workers. Mutat Res. Aug 9; [Epub ahead of print]

Soucek P, Borovanova T, Pohlreich P, Kleibl Z, Novotny J. (2007) Role of Single Nucleotide Polymorphisms and Haplotypes in BRCA1 in Breast Cancer: Czech Case-Control Study. Breast Cancer Res Treat.103(2):219-224.

Vodicka P, Stetina R, Polakova V, Tulupova E, Naccarati A, Vodickova L, Kumar R, Hanova M, Pardini B, Slyskova J, Musak L, De Palma G, Soucek P, Hemminki K. (2007) Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. Carcinogenesis, 28(3):657-664.

Václavíková R, Hubáčková M, Kubala E, Kodet R, Mrhalová M, Novotný J, Gut I a Souček P. (2007) Exprese genu mnohočetné lékové rezistence 1 (MDR1) a její význam v rozvoji a terapii karcinomu prsu. Klinická Onkologie, 3:253-259.

Vaclavikova R, Hubackova M, Stribrna-Sarmanova, J, Kodet R, Mrhalova M, Novotny J and Soucek P. (2007) RNA expression of cytochromes P450 in breast cancer patients. Anticancer Res. 27(6C):4443-50.

vydané v roce 2006:
Gut I, Václavíková R, Simek P, Ojima I, Horsky S, Soucek P, Kondrova E: Metabolism of New Generation Taxanes in Human, Pig, Minipig and Rat Liver Microsomes. Xenobiotica 36(9):772-92.

Kondrová E, Ozgová Š, Gut I (2006) Přirozené polyfenoly jako antoxidanty a prooxidanty a mechanismy jejich působení. České pracovní lékařství in press (in Czech).

Naccarati A, Soucek P, Stetina R, Haufroid V, Kumar R, Vodickova L, Trtkova K, Dusinska M, Hemminki K, and Vodicka P. (2006) Genetic polymorphisms and possible gene-gene interactions in metabolic and dna repair genes: effects on DNA damage. Mutat. Res.-Fund. Mol. M, 593(1-2):22-31.

Otova B, Vaclavikova R, Ehrlichova M, Horsky S, Soucek P, Simek P, Gut I. (2006) Effects of paclitaxel, docetaxel and their combinations on subcutaneous lymphomas in inbred Sprague-Dawley/Cub rats. Eur J Pharm Sci, 29(5):442-450.

Stiborová M, Dračínská H, Hájková J, Kadeřábková P, Frei E, Schmeiser HH, Souček P, Phillips DH, and Arlt VM (2006) The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase. Drug Metab. Dispos., 34:1398-1405.

Šůsová S, Trněný M, and Souček P (2006) Single nucleotide polymorphism in 5´-flanking region of BCL6 is not associated with increased risk of non-Hodgkin´s lymphoma. Cancer Lett., 238:142-145.

Vaclavikova R, Boumendjel A, Ehrlichova M, Kovar J, Gut I. (2006) Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport? Bioorg. Med. Chem., 14(13):4519-4525.

Vodicka PE, Linhart I, Novak J, Koskinen M, Vodickova L, Hemminki K. (2006) 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation. Toxicol. Appl. Pharmacol., 210(1-2):1-8.

Vodicka P, Stetina R, Smerak P, Vodickova L, Naccarati A, Barta I, Hemminki K. (2006) Micronuclei, DNA single-strand breaks and DNA-repair activity in mice exposed to 1,3-butadiene by inhalation. Mutat. Res., 608(1):49-57.

Vodicka P, Koskinen M, Naccarati A, Oesch-Bartlomowicz B, Vodickova L, Hemminki K, Oesch F. (2006) Styrene metabolism, genotoxicity, and potential carcinogenicity. Drug Metab Rev., 38(4):805-53.

Walsh T, Casadei S, Coats KH, Swisher E, Stray SM, Higgins J, Roach KC, Mandell J, Lee MK, Ciernikova S, Foretova L, Soucek P, King MC. (2006) Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. JAMA, 295(12):1379-1388.

vydané v roce 2005:
Anzenbacherova E, Baranova J, Zuber R, Pechova A, Anzenbacher P, Soucek P, Martinkova J. (2005) Model Systems Based on Experimental Animals for Studies on Drug Metabolism in Man: (Mini)Pig Cytochromes P450 3A29 and 2E1. Basic Clin. Pharmacol. Toxicol., 96(3):244-245.

Baranová J, Anzenbacherová E, Anzenbacher P, and Souček P (2005) Minipig Cytochrome P450 2E1: Comparison with Human Enzyme. Drug Metab. Dispos., 33(6):862-865.

Ehrlichova M, Vaclavikova R, Ojima I, Pepe A, Kuznetsova LV, Chen J, Truksa J, Kovar J, Gut I. (2005) Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells. Naunyn Schmiedebergs Arch. Pharmacol., 372(1):95-105.

Ehrlichova M, Koc M, Truksa J, Naldova Z, Vaclavikova R, Kovar J. (2005) Cell death induced by taxanes in breast cancer cells: cytochrome C is released in resistant but not in sensitive cells. Anticancer Res., 25(6B):4215-4224.

Kuricova M, Naccarati A, Kumar R, Koskinen M, Sanyal S, Dusinska M, Tulinska J, Vodickova L, Liskova A, Jahnova E, Fuortes L, Haufroid V, Hemminki K, Vodicka P. (2005) DNA repair and cyclin D1 polymorphisms and styrene-induced genotoxicity and immunotoxicity. Toxicol. Appl. Pharmacol., 207(2 Suppl):302-9.

Souček P, Anzenbacher P, Skoumalová I, and Dvořák M (2005) Expression of Cytochrome P450 Genes in CD34+ Hematopoietic Stem and Progenitor Cells. Stem Cells, 23:1417-1422.

Šůsová S, Novotný J, Vodička P a Souček P. (2005) Úloha genetických polymorfismů biotransformačních enzymů v rozvoji kolorektálního karcinomu. Klin. Onkol., 18:188-193 (in Czech).

vydané v roce 2004:
Kubrycht J, Borecky J, Soucek P, Jezek P. (2004) Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: cell adhesion molecule from the living fossil sponge Geodia cydonium. Mapping of coherent database similarities and implications for evolution of CDR1 and hypermutation. Folia Microbiol., 49(3):219-246.

Menzel H-J, Sarmanova J, Soucek P, Berberich R, Grünewald K, Haun M, Kraft H-G. (2004) Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations. Br. J. Cancer, 90:1989-1994.

Soucek P, Skjelbred CF, Svendsen M, Kristensen T, Kure EH, Kristensen VN. (2004) Single-track sequencing for genotyping of multiple SNPs in the N-acetyltransferase 1 (NAT1) gene. BMC Biotechnol., 254(1):28.

Szotáková B, Baliharová B, Lamka J, Nožinová E, Wsól V, Velík J, Machala M, Neča J, Souček P, Šůsová S and Skálová L. (2004) Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat, and sheep. Res. Vet. Sci., 76:43-51.

Šarmanová J, Šůsová S, Gut I, Mrhalová M, Kodet R, Adámek J, Roth Z, and Souček P. (2004) Breast cancer: role of polymorphisms in biotransformation enzymes. Eur. J. Hum. Genet., 12(10):848-854.

Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, and Gut I. (2004) Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Drug Metab. Dispos.,32:666-674.

Vodička P, Kumar R, Stetina R, Sanyal S, Soucek P, Haufroid V, Dusinska M, Kuricova M, Zamecnikova M, Musak L, Buchancova J, Norppa H, Hirvonen A, Vodickova L, Naccarati A, Matousu Z and Hemminki K (2004). Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. Carcinogenesis, 25:757-763.

Vodicka P, Kumar R, Stetina R, Musak L, Soucek P, Haufroid V, Sasiadek M, Vodickova L, Naccarati A, Sedikova J, Sanyal S, Kuricova M, Brsiak V, Norppa H, Buchancova J and Hemminki K. (2004) Markers of individual susceptibility and DNArepair rate in workers exposed to xenobiotics in a tire plant. Environ. Molec. Mutagen., 44(4):283-292.

Vodicka P, Tuimala J, Stetina R, Kumar R, Manini P, Naccarati A, Maestri L, Vodickova L, Kuricova M, Jarventaus H, Majvaldova Z, Hirvonen A, Imbriani M, Mutti A, Migliore L, Norppa H, Hemminki K. (2004) Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers. Environ. Health Perspect., 112(8):867-871.